Cannabidiol is an extract from cannabis plants that has become legal for supplemental use throughout the United States. In this video we discuss the benefits of taking CBD for anxiety disorders. Below are the articles mentioned in the video:
Shannon, S., Lewis, N., Lee, H., & Hughes, S. (2019). Cannabidiol in Anxiety and Sleep: A Large Case Series. Permanente Journal, 23(1), 21–25. https://doi-org.ezproxy.uvu.edu/10.7812/TPP/18-041
Conclusion: Cannabidiol may hold benefits for anxiety-related disorders. Controlled clinical studies are needed.
Erin L. Martin, Justin C. Strickland, Nicolas J. Schlienz, Joel Munson, Heather Jackson, Marcel O. Bonn-Miller, & Ryan Vandrey. (2021). Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial. Frontiers in Psychiatry, 12. https://doi-org.ezproxy.uvu.edu/10.3389/fpsyt.2021.729800
Conclusions: Medicinal cannabis use may reduce anxiety and depressive symptoms in clinically anxious and depressed populations. Future placebo-controlled studies are necessary to replicate these findings and to determine the route of administration, dose, and product formulation characteristics to optimize clinical outcomes.
Crippa, J. A. S., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L. S., Martin-Santos, R., Simões, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Filho, A. S., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. C. (2011). Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: A preliminary report. Journal of Psychopharmacology, 25(1), 121–130. https://doi-org.ezproxy.uvu.edu/10.1177/0269881110379283
This study demonstrated that acute administration of CBD, one of the main psychoactive constituents of Cannabis sativa, can reduce subjective anxiety in patients clinically diagnosed with an anxiety disorder, in this case SAD. Furthermore, the present study indicates that this behavioral response is associated with changes in the functional activity of brain areas implicated in the processing of anxiety.
Garner-Wizard, M. (2021). Review Finds CBD Has Therapeutic Potential for Anxiety Disorders. HerbalGram, 129, 38–39. https://doi-org.ezproxy.uvu.edu/10.1016/j.japh.2019.11.008.
In the eight studies reviewed, CBD regularly produced improvements in SAD, GAD, and anxiety related to PTSD. However, the small sample sizes, low statistical power of many of the studies, and use of subjective self-report measures, among other limitations, make it necessary to interpret results with caution. These authors also did not provide a quality assessment of included studies.
CBD Dosage for Anxiety
You also have to find the right CBD dosage for your anxiety. Experts suggest starting small and working your way up depending on how your body reacts.
Many clinical trials jump right to testing high doses. Successful doses evaluated for anxiety relief specifically include:
600 milligrams in patients with SAD in a speech simulation
300 milligrams in male patients in a speech simulation
However, other trials suggest much lower doses are also quite effective in treating anxiety.
25 to 75 milligrams for generalized anxiety and/or sleep problems
33 to 49 milligrams a day for PTSD, in addition to routine psychiatric treatment
Another study involving hundreds of patients noted success with doses from 40 milligrams to 300 milligrams a day, further supporting the idea that CBD dosage varies significantly, depending on a person’s symptoms and physiology.